LA THALASSEMIE PDF

Thalassemia is a chronic, inherited microcyric anemia characterized by defective hemoglobin synthesis. Thalassemia is common in mediterranean and middle east countries. In all types of thalassemia, clinical features that result from anemia, transfusional, and absorptive iron overload are similar but vary in severity. Other complications include growth retardation, bone deformation and marrow hyperplasia which are avoided by regular blood transfusion. The skeletal X-ray findings show characteristies of chronic overactivity of the marrow. The MRI appearance of marrow is a reflection of transfusion and chelation therapy.

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Eighty-five cases of beta-thalassemia minor were found between January and November in 18 families of French-speaking Quebeckers without Mediterranean ancestry. Most of the families had settled in Quebec more than years ago, largely in Portneuf county. This is the first report of such a number of cases of beta-thalassemia in this population.

Thus, beta-thalassemia minor is a relatively common condition in Quebec and must be considered in cases of microcytic anemia without evidence of iron deficiency. The hematologic findings were similar to those reported in the past in other populations. Two cases of delta beta-thalassemia minor in sisters are also reported; this is the first report of such cases in French Canadians.

National Center for Biotechnology Information , U. Can Med Assoc J. Desjardins , C. Rousseau , J. Duplain , J. Valet , and P. Copyright and License information Disclaimer. Copyright notice. This article has been cited by other articles in PMC. Abstract Eighty-five cases of beta-thalassemia minor were found between January and November in 18 families of French-speaking Quebeckers without Mediterranean ancestry.

Union Med Can. Thalassemia in Canadians. Estimation of small percentages of foetal haemoglobin. Glycerol lysis time as a screening test for erythrocyte disorders. J Lab Clin Med. Haematological data in cases of -thalassaemia trait in Thailand. Br J Haematol. Thalassaemia in the British.

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