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A bioassay-guided isolation of the ethanol extract from the fruits of Piper longum yielded a known piperidine alkaloid, piperine, as a monoamine oxidase MAO inhibitor. The inhibition by piperine was found to be reversible by dialysis of the incubation mixture. In addition, the immobility times in the tail suspension test were significantly reduced by piperine, similar to that of the reference antidepressant fluoxetine, without accompanying changes in ambulation when assessed in an open-field.

These results suggest that piperine possesses potent antidepressant-like properties that are mediated in part through the inhibition of MAO activity, and therefore represent a promising pharmacotherapeutic candidate as an antidepressant agent. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Full-text links Cite Favorites. Abstract A bioassay-guided isolation of the ethanol extract from the fruits of Piper longum yielded a known piperidine alkaloid, piperine, as a monoamine oxidase MAO inhibitor.

Similar articles Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase. Lee SA, et al. Arch Pharm Res. Epub Jun PMID: Antidepressant-like effects of piperine and its derivative, antiepilepsirine.

Li S, et al. J Asian Nat Prod Res. Involvement of serotonergic system in the antidepressant-like effect of piperine. Mao QQ, et al. Prog Neuropsychopharmacol Biol Psychiatry. Epub Apr 6. Piperine and Its Role in Chronic Diseases. Derosa G, et al. Adv Exp Med Biol. PMID: Review. Piper nigrum and piperine: an update. Meghwal M, Goswami TK. Meghwal M, et al. Phytother Res. Epub Apr Show more similar articles See all similar articles.

Cited by 23 articles Natural phenolic derivatives based on piperine scaffold as potential antifungal agents. Wang J, et al. BMC Chem. Thawabteh A, et al. Toxins Basel. Black pepper and its bioactive constituent piperine: promising therapeutic strategies for oral lichen planus. Yang JY, et al. Epub Oct Chauhan PS, et al. Ramesh B, et al. J Pharm Anal. Epub Jul Show more "Cited by" articles See all "Cited by" articles. Publication types Research Support, Non-U.

Gov't Actions. Animals Actions. Benzodioxoles Actions. Male Actions. Mice Actions. Polyunsaturated Alkamides Actions. Substances Alkaloids Actions. Antidepressive Agents Actions. Monoamine Oxidase Inhibitors Actions. Piperidines Actions. Copy Download.



Mauzshura Additional work is needed to confirm the findings with more Salmonella serotypes and strains. The hydroethanolic extract of Piper aduncum and its component proteins increased the proliferation and migration of hDFa and increased the expression of growth factors involved in the healing process. Other biochemical constituents such as oleoresin, piperine and essential oils were found in the acceptable range. Diabetes mellitus is an important human disease afflicting many from various walks of life in different countries. Results of the research showed that there were 8 species found as cultivated plants in Yogyakarta, which were P. The results of the postfumigation studies indicated that Salmonella Enteritidis was absent in the fumigated grains after drying and storage for 72 h, indicating a promising application for this technique. The presence of a large number of phytopathogenic fungi on sorghum seed should be further investigated in order to clarify their relationships and relative significance.


Physicochemical properties of black pepper Piper nigrum starch. Black pepper Piper nigrum is among the most popular spices around the world. Starch is the major component of black pepper. However, little is known about functional properties of this starch.


Abrahim, N. Piper betle shows antioxidant activities, inhibits MCF-7 cell proliferation and increases activities of catalase and superoxide dismutase. Alam, B. Antioxidant, analgesic and anti inflam-matory activities of the methanolic extract of Piper betle leaves.

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