The only unifying thread is that they contain nitrogen in some way. What prompts this, you might ask? No good answer. So what the hell. Why not now? The Hofmann and Curtius rearrangements are two examples of a whole family of rearrangement reactions that share a common mechanistic step.

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By using our site, you acknowledge that you have read and understand our Cookie Policy , Privacy Policy , and our Terms of Service. Chemistry Stack Exchange is a question and answer site for scientists, academics, teachers, and students in the field of chemistry. It only takes a minute to sign up. I already know the mechanism the question is the water molecules that is attacked by the isocyanide is it already present in the solution or is the one formed within the reaction in situ?

However, there is a second problem with this:. It does not even matter mechanistically what the pathway is. In general, protonation can and will occur by any solvent molecule that happens to be close by. Sign up to join this community. The best answers are voted up and rise to the top. Home Questions Tags Users Unanswered. Ask Question. Asked 3 years, 1 month ago. Active 3 years, 1 month ago. Viewed 1k times. So the main question are :- 1 Are the water molecules the ones generated in situ?

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FAQ on Hoffmann Bromamide Reaction in JEE

The Hofmann rearrangement is the organic reaction of a primary amide to a primary amine with one fewer carbon atom. The reaction is named after its discoverer — August Wilhelm von Hofmann. This reaction is also sometimes called the Hofmann degradation , and should not be confused with the Hofmann elimination. The reaction of bromine with sodium hydroxide forms sodium hypobromite in situ , which transforms the primary amide into an intermediate isocyanate. The formation of an intermediate nitrene is not possible because it implies also the formation of a hydroxamic acid as a byproduct, which has never been observed. The intermediate isocyanate is hydrolyzed to a primary amine, giving off carbon dioxide.


Write Short Notes on the Following Hofmann’S Bromamide Reaction - Chemistry



The Hofmann and Curtius Rearrangements


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