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Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum SC acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular carrier containing high ethanol concentrations and offer improved skin permeability and efficient bioavailability due to their structure and composition.
This article gives a review of ethosomes including their compositions, types, mechanism of drug delivery, stability, and safety behaviour.
This article also provides a detailed overview of drug delivery applications of ethosomes in various diseases. Keywords: Drug delivery applications; ethosomes; mechanism of delivery; safety; stability.
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Similar articles Combinations of nanovesicles and physical methods for enhanced transdermal delivery of a model hydrophilic drug. Zorec B, et al. Eur J Pharm Biopharm. Epub Mar PMID: Mechanism of transdermal permeation promotion of lipophilic drugs by ethosomes. Yang L, et al. Int J Nanomedicine. Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. Dubey V, et al. J Control Release. Epub Aug Ethosomes and Transfersomes: Principles, Perspectives and Practices.
Garg V, et al. Curr Drug Deliv. PMID: Review. Akhtar N, et al. Curr Clin Pharmacol. Show more similar articles See all similar articles. Publication types Review Actions. Animals Actions. Chemistry, Pharmaceutical Actions. Drug Liberation Actions. Drug Therapy Actions. Humans Actions. Hydrophobic and Hydrophilic Interactions Actions. Permeability Actions.
Skin Absorption Actions. Substances Liposomes Actions. Phospholipids Actions. Ethanol Actions. Copy Download.
Transdermal Applications of Ethosomes - A Detailed Review
Androgenetic alopecia male-pattern hair loss is characterized by the deposition of dihydrotestosterone at the pilosebaceous unit of the scalp. Oral administration of drugs like finasteride which can reverse androgenic alopecia causes undesired effects to the body. Targeting these drugs directly to the pilosebaceous unit of the scalp will enhance the pharmacological response at the desired site by reducing undesired systemic side effects. This chapter discusses about ethosomes, a specially tailored ethanolic vesicular carriers which can efficiently deliver various drugs with different physicochemical properties to and through the skin. The unique characteristics of the ethosomal carriers, their composition, preparation methods, and the mechanism of permeation, safety, and practical experience finasteride and herbal extracts have been discussed in detail.
Ethosomes: An Exciting and Promising Alcoholic Carrier System for Treating Androgenic Alopecia