Chronic Myeloide Leukemia: natural history and classification. Chiattone II. CML is a clonal disease characterized by balanced translocation between chromosomes 9 and 22 Philadelphia chromosome. The disease is characterized by a triphasic course that includes a chronic phase CP , an accelerated phase AP and an acute or blastic phase BP. Unless the disease is controlled or eliminated, patients progress to AP and BF in variable periods of time. Several staging classification systems are used for CML all of which were designed in the pre-imatinib era.
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Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed. Its annual incidence has been estimated at between 1 and 1. The majority of patients are diagnosed in the chronic phase and may be either asymptomatic diagnosed through a routine white blood cell count or present with fatigue, anaemia, weight loss, night sweats or splenomegaly. CML is characterised by the presence of the Philadelphia chromosome, an abnormality resulting from a balanced translocation between chromosomes 9 and 22 t 9;22 q34;q CML does not appear to be an inherited disease and the factors leading to predisposition for the disorder remain largely unknown.
¿Qué causa la leucemia mieloide crónica?