Gilhotra 3. The point of this review is to think about hepatoprotective movement of lycopene and non lycopene containing part of tomato concentrate to investigate the likelihood that a few constituents other than lycopene may be in charge of hepatoprotective action. Writing uncovered that plant containing Carotenoids, Lycopene, Carotene, Xanthophylls, Xanthophylls Ester mixes were in charge of hepatoprotective action and they chose plant additionally having these constituent so it was conjectured that it might likewise have the capacity to ensure the liver. Keeping this view exhibit study is meant to arrange the work for the impact of hepatoprotective action of Lycopersicon esculentum. Paracetamol-initiated liver rot was repressed essentially by methanolic-I extricate Non-lycopene fractionate of Lycopersicon esculentum.

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Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Methods: The study was carried out in 70 Wistar rats in two phases. In phase I, models of paracetamol and anti-tubercular drugs induced hepatotoxicity were standardized in 22 Wistar rats and in phase II, hepatoprotective potential of lycopene was evaluated in paracetamol and anti-tubercular drugs induced hepatic damage using 48 Wistar rats.

The effects of lycopene were compared with silymarin. Conclusions: The results of the present study prove that lycopene exerts hepatoprotective effect against paracetamol and anti-tubercular drugs induced hepatic damage in rats. Lycopene needs to be evaluated in other models of hepatotoxicity and further studies are required to delineate its mechanism of action.

Lycopene could be a potential hepatoprotective for clinical use in future. Results of a prospective study of acute liver failure at 17 tertiary care centers in the US. Annals Internal Medicine.

Risk factors of hepatotoxicity during anti-tubercular treatment. Protective effect of lycopene against radiation-induced hepatic toxicity in rats. The Journal of International Medical Research. International Journal of Pharma Sciences. The role of the antioxidants lycopene and vitamin E in the prevention of halothane-induced hepatotoxicity. Methods Find Exp Clin Pharmacol.

Rao AV, Agarwal S. Role of antioxidant lycopene in cancer and heart disease. J Am Coll Nutr. Zimmerman HJ. Drug Hepatotoxicity: Spectrum of clinical lesions. In Drug Reactions and the Liver, eds. Sheriff S, Devaki T. Journal of Taibah University for Science. Effects of lycopene against cisplatin induced nephrotoxicity and oxidative stress in rats. Protective effect of lycopene on adriamycin induced cardiotoxicity and nephrotoxicity.

Acetaminophen-induced acute liver failure: results of U S. Multi-center prospective study. Etiology and outcome of acute liver failure in the USA: preliminary results of a prospective multi-center study. User Username Password Remember me. Font Size. Notifications View Subscribe. Article Tools Print this article. Indexing metadata. How to cite item. Finding References. Email this article Login required. Abstract Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects.

Full Text: PDF. Lewis JH. Drug induced liver disease. Advances in gastroenterology. Remember me.


Lycopene's Effects on Health and Diseases

Bisphenol A BPA -an endocrine disruptor xenoestrogen-is widely spread in the environment. Lycopene LYC is an antioxidant phytochemical carotenoid. The hereby study was designed to verify the deleterious effect of BPA on cyclic female rats' hepatic tissue as well as evaluation of the effect of LYC toward BPA hepatic perturbation. The treatments were given daily via gavage to the rats for 30 days. The rats in BPA displayed high activities of serum liver enzymes with low levels of total proteins TP and albumin. Meanwhile, LYC administration reduced the cytotoxic effects of BPA on hepatic tissue, through improving the liver function biomarkers and oxidant-antioxidant state as well as DNA damage around the control values.


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Items in TSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Description: Objective : To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea P. Materials and Methods : Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of carbon tetrachloride 0. The aqueous extract of P. The hepatoprotective activity of the combination was evaluated by the liver function marker enzymes in the serum [aspartate transaminases AST , alanine transaminases ALT , alkaline phosphatase Alk. Results : Both the treatment groups showed hepatoprotective effect against carbon tetrachloride induced hepatotoxicity by significantly restoring the levels of serum enzymes to normal which was comparable to that of silymarin group. Besides, the results obtained from PST and histopathological results also support the study.

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